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1

3D-QSAR Studies on Cannabinoid CB1 Receptor Agonists: G-Protein Activation as Biological Data

Salo, Outi M. H., Savinainen, Juha R., Parkkari, Teija, Nevalainen, Tapio, Lahtela-Kakkonen, Maija, Gynther, Jukka, Laitinen, Jarmo T., Järvinen, Tomi, Poso, Antti

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 420 KB

english, 2006

2

A Randomized Clinical Trial of Histamine 2 Receptor Antagonism in Treatment-Resistant Schizophrenia

Meskanen, Katarina, Ekelund, Heidi, Laitinen, Jarmo, Neuvonen, Pertti J., Haukka, Jari, Panula, Pertti, Ekelund, Jesper

Journal:

Journal of Clinical Psychopharmacology

Year:

2013

Language:

english

File:

PDF, 1.01 MB

english, 2013

3

Monoglyceride Lipase as an Enzyme Hydrolyzing 2-Arachidonoylglycerol

Susanna M. Saario, Jarmo T. Laitinen

Journal:

Chemistry & Biodiversity

Year:

2007

Language:

english

File:

PDF, 293 KB

english, 2007

4

Screening of Various Hormone-Sensitive Lipase Inhibitors as Endocannabinoid-Hydrolyzing Enzyme Inhibitors

Anna Minkkilä, Juha R. Savinainen, Heikki Käsnänen, Henri Xhaard, Tapio Nevalainen, Jarmo T. Laitinen, Antti Poso, Jukka Leppänen, Susanna M. Saario

Journal:

Year:

2009

Language:

english

File:

PDF, 700 KB

english, 2009

5

Synthesis and CB1 receptor activities of dimethylheptyl derivatives of 2-arachidonoyl glycerol (2-AG) and 2-arachidonyl glyceryl ether (2-AGE)

Teija Parkkari, Outi M.H. Salo, Kristiina M. Huttunen, Juha R. Savinainen, Jarmo T. Laitinen, Antti Poso, Tapio Nevalainen, Tomi Järvinen

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 184 KB

english, 2006

6

Synthesis, cannabinoid receptor activity, and enzymatic stability of reversed amide derivatives of arachidonoyl ethanolamide

Teija Parkkari, Juha R. Savinainen, Katri H. Raitio, Susanna M. Saario, Laura Matilainen, Tuomas Sirviö, Jarmo T. Laitinen, Tapio Nevalainen, Riku Niemi, Tomi Järvinen

Journal:

Bioorganic & Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 159 KB

english, 2006

7

Characterization of binding properties of monoglyceride lipase inhibitors by a versatile fluorescence-based technique

Juha R. Savinainen, Megumi Yoshino, Anna Minkkilä, Tapio Nevalainen, Jarmo T. Laitinen

Journal:

Analytical Biochemistry

Year:

2010

Language:

english

File:

PDF, 188 KB

english, 2010

8

Synthesis and CB1 receptor activities of novel arachidonyl alcohol derivatives

Teija Parkkari, Juha R. Savinainen, Anu L. Rauhala, Tiina L. Tolonen, Tapio Nevalainen, Jarmo T. Laitinen, Jukka Gynther, Tomi Järvinen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 298 KB

english, 2004

9

Characterization of the Sulfhydryl-Sensitive Site in the Enzyme Responsible for Hydrolysis of 2- Arachidonoyl-Glycerol in Rat Cerebellar Membranes

Susanna M. Saario, Outi M.H. Salo, Tapio Nevalainen, Antti Poso, Jarmo T. Laitinen, Tomi Järvinen, Riku Niemi

Journal:

Chemistry & Biology

Year:

2005

Language:

english

File:

PDF, 301 KB

english, 2005

10

URB754 Has No Effect on the Hydrolysis or Signaling Capacity of 2-AG in the Rat Brain

Susanna M. Saario, Ville Palomäki, Marko Lehtonen, Tapio Nevalainen, Tomi Järvinen, Jarmo T. Laitinen

Journal:

Chemistry & Biology

Year:

2006

Language:

english

File:

PDF, 142 KB

english, 2006

11

Quantification of lysophosphatidic acids in rat brain tissue by liquid chromatography–electrospray tandem mass spectrometry

Niina Aaltonen, Jarmo T. Laitinen, Marko Lehtonen

Journal:

Journal of Chromatography B

Year:

2010

Language:

english

File:

PDF, 825 KB

english, 2010

12

Nocturnal 6-hydroxymelatonin sulfate excretion in female workers exposed to magnetic fields

Jukka Juutilainen, Richard G. Stevens, Larry E. Anderson, Norman H. Hansen, Marko Kilpeläinen, Timo Kumlin, Jarmo T. Laitinen, Eugene Sobel, Bary W. Wilson

Journal:

Journal of Pineal Research

Year:

2000

Language:

english

File:

PDF, 206 KB

english, 2000

13

Guanosine 5′-(γ-[35S]Thio)triphosphate Autoradiography Allows Selective Detection of Histamine H3 Receptor-Dependent G Protein Activation in Rat Brain Tissue Sections

Jarmo T. Laitinen, Marianne Jokinen

Journal:

Journal of Neurochemistry

Year:

1998

Language:

english

File:

PDF, 1.45 MB

english, 1998

14

Protective Properties of Tin- and Manganese-Centered Porphyrins Against Hydrogen Peroxide-Mediated Injury in Rat Astroglial Cells

Barney E. Dwyer, Shi-Yi Lu, Jarmo T. Laitinen, Robert N. Nishimura

Journal:

Journal of Neurochemistry

Year:

1998

Language:

english

File:

PDF, 1.05 MB

english, 1998

15

[35S]GTPγS autoradiography reveals a wide distribution of Gi/o-linked ADP receptors in the nervous system: close similarities with the platelet P2YADP receptor

Jarmo T. Laitinen, Asko Uri, Gerda Raidaru, Riitta Miettinen

Journal:

Journal of Neurochemistry

Year:

2001

Language:

english

File:

PDF, 1012 KB

english, 2001

16

S-Nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner

Tarja Kokkola, Juha R Savinainen, Kati S Mönkkönen, Montse Durán Retamal, Jarmo T Laitinen

Journal:

BMC Cell Biology

Year:

2005

Language:

english

File:

PDF, 4.16 MB

english, 2005

17

Cholinergic signaling in the rat pineal gland

Jarmo T. Laitinen, Kirsti S. M. Laitinen, Tarja Kokkola

Journal:

Cellular and Molecular Neurobiology

Year:

1995

Language:

english

File:

PDF, 1.23 MB

english, 1995

18

Community and species responses to water level fluctuations with reference to soil layers in different habitats of mid-boreal mire complexes

Jarmo Laitinen, Sakari Rehell, Jari Oksanen

Journal:

Year:

2008

Language:

english

File:

PDF, 684 KB

english, 2008

19

Mechanism by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) reduces circulating melatonin levels in the rat

Raimo Pohjanvirta, Jarmo T. Laitinen, Olli Vakkuri, Jere Lindén, Tarja Kokkola, Mikko Unkila, Jouko Tuomisto

Journal:

Year:

1996

Language:

english

File:

PDF, 1.21 MB

english, 1996

20

α-Methylated derivatives of 2-arachidonoyl glycerol: Synthesis, CB1 receptor activity, and enzymatic stability

Teija Parkkari, Mikko Myllymäki, Juha R. Savinainen, Susanna M. Saario, Joel A. Castillo-Meléndez, Jarmo T. Laitinen, Tapio Nevalainen, Ari M.P. Koskinen, Tomi Järvinen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 114 KB

english, 2006

21

Long-term Induction of Haem Oxygenase-1 (HSP-32) in Astrocytes and Microglia Following Transient Focal Brain Ischaemia in the Rat

Jari Koistinaho, Susanna Miettinen, Riitta Keinänen, Nina Vartiainen, Reina Roivainen, Jarmo T. Laitinen

Journal:

European Journal of Neuroscience

Year:

1996

Language:

english

File:

PDF, 2.62 MB

english, 1996

22

Differential Sensitivity to Cations of the Melatonin Receptors in the Rat Area Postrema and Suprachiasmatic Nuclei

Jarmo T. Laitinen, Juan M. Saavedra

Journal:

Journal of Neurochemistry

Year:

1990

Language:

english

File:

PDF, 360 KB

english, 1990

23

Visualization of 2-arachidonoylglycerol accumulation and cannabinoid CB1 receptor activity in rat brain cryosections by functional autoradiography

Ville A. B. Palomäki, Marko Lehtonen, Juha R. Savinainen, Jarmo T. Laitinen

Journal:

Journal of Neurochemistry

Year:

2007

Language:

english

File:

PDF, 774 KB

english, 2007

24

Different patterns of light exposure in relation to melatonin and Cortisol rhythms and sleep of night workers

Margit Koller, Mikko Härma, Jarmo T. Laitinen, Michael Kundi, Brigitte Piegler, Manfred Haider

Journal:

Journal of Pineal Research

Year:

1994

Language:

english

File:

PDF, 801 KB

english, 1994

25

Effects of melatonin implants on winter fur growth and testicular recrudescence in adult male raccoon dogs (Nyctereutes procyonoides)

Yongjun Xiao, Mats Forsberg, Jarmo T. Laitinen, Maija Valtonen

Journal:

Journal of Pineal Research

Year:

1996

Language:

english

File:

PDF, 876 KB

english, 1996

26

The functional role of cysteines adjacent to the NRY motif of the human MT1 melatonin receptor

Tarja Kokkola, Outi M. H. Salo, Antti Poso, Jarmo T. Laitinen

Journal:

Journal of Pineal Research

Year:

2005

Language:

english

File:

PDF, 417 KB

english, 2005

27

Inverse agonist exposure enhances ligand binding and G protein activation of the human MT1 melatonin receptor, but leads to receptor down-regulation

Tarja Kokkola, Maija Vaittinen, Jarmo T. Laitinen

Journal:

Journal of Pineal Research

Year:

2007

Language:

english

File:

PDF, 609 KB

english, 2007

28

Therapeutic Potential of Endocannabinoid-Hydrolysing Enzyme Inhibitors

Susanna M. Saario, Jarmo T. Laitinen

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2007

Language:

english

File:

PDF, 136 KB

english, 2007

29

Despite substantial degradation, 2-arachidonoylglycerol is a potent full efficacy agonist mediating CB1 receptor-dependent G-protein activation in rat cerebellar membranes

Juha R Savinainen, Tomi Järvinen, Krista Laine, Jarmo T Laitinen

Journal:

British Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 252 KB

english, 2001

30

An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors

Juha R Savinainen, Susanna M Saario, Riku Niemi, Tomi Järvinen, Jarmo T Laitinen

Journal:

British Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 200 KB

english, 2003

31

Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor

Juha R Savinainen, Tarja Kokkola, Outi M H Salo, Antti Poso, Tomi Järvinen, Jarmo T Laitinen

Journal:

British Journal of Pharmacology

Year:

2005

Language:

english

File:

PDF, 307 KB

english, 2005

32

The ‘allosteric modulator’ SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms

Anna M Lewandowicz, Jouko Vepsäläinen, Jarmo T Laitinen

Journal:

British Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 380 KB

english, 2006

33

Dopamine Stimulates K+ Efflux in the Chick Retina via D1 Receptors Independently of Adenylyl Cyclase Activation

Jarmo T. Laitinen

Journal:

Journal of Neurochemistry

Year:

1993

Language:

english

File:

PDF, 851 KB

english, 1993

34

Post-Impulsive-Phase Acceleration in a Wide Range of Solar Longitudes

Leon Kocharov, Jarmo Torsti, Timo Laitinen, Matti Teittinen

Journal:

Year:

1999

Language:

english

File:

PDF, 115 KB

english, 1999

35

Effects of Topical Anandamide-Transport Inhibitors, AM404 and Olvanil, on Intraocular Pressure in Normotensive Rabbits

Krista Laine, Tomi Järvinen, Juha Savinainen, Jarmo T. Laitinen, David W. Pate, Kristiina Järvinen

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 208 KB

english, 2001

36

Virtual Screening of Novel CB2 Ligands Using a Comparative Model of the Human Cannabinoid CB2 Receptor

Raitio, Katri H., Savinainen, Juha R., Nevalainen, Tapio, Lahtela-Kakkonen, Maija, Laitinen, Jarmo T., Järvinen, Tomi, Poso, Antti, Salo, Outi M. H.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 255 KB

english, 2005

37

Differential regulation of cyclic GMP levels in the frontal cortex and the cerebellum of anesthetized rats by nitric oxide: an in vivo microdialysis study

Jarmo T. Laitinen, Kirsti S.M. Laitinen, Leena Tuomisto, Mauno M. Airaksinen

Journal:

Year:

1994

Language:

english

File:

PDF, 504 KB

english, 1994

38

A sensitive microassay reveals marked regional differences in the capacity of rat brain to generate carbon monoxide

Jarmo T. Laitinen, Risto O. Juvonen

Journal:

Year:

1995

Language:

english

File:

PDF, 763 KB

english, 1995

39

Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes

Susanna M Saario, Juha R Savinainen, Jarmo T Laitinen, Tomi Järvinen, Riku Niemi

Journal:

Biochemical Pharmacology

Year:

2004

Language:

english

File:

PDF, 143 KB

english, 2004

40

Fetal cardiac sympathetic activation is linked with maternal body mass index

Tiina Ojala, Jonna Aaltonen, Saila Siira, Jarmo Jalonen, Eeva Ekholm, Ulla Ekblad, Kirsi Laitinen

Journal:

Early Human Development

Year:

2009

Language:

english

File:

PDF, 164 KB

english, 2009

41

Important amino acids for the function of the human MT1 melatonin receptor

Tarja Kokkola, Steven M. Foord, Marie-Ange Watson, Olli Vakkuri, Jarmo T. Laitinen

Journal:

Biochemical Pharmacology

Year:

2003

Language:

english

File:

PDF, 317 KB

english, 2003

42

Regulation of cyclic GMP levels in the rat frontal cortex in vivo: effects of exogenous carbon monoxide and phosphodiesterase inhibition

Kirsti S.M. Laitinen, Kari Salovaara, Silvia Severgnini, Jarmo T. Laitinen

Journal:

Year:

1997

Language:

english

File:

PDF, 226 KB

english, 1997

43

[γ-35S]GTP autoradiography allows region-specific detection of muscarinic receptor-dependent G-protein activation in the chick optic tectum

Kaisa M.A Kurkinen, Jari Koistinaho, Jarmo T Laitinen

Journal:

Year:

1997

Language:

english

File:

PDF, 309 KB

english, 1997

44

Effects of low-frequency magnetic fields on implantation in rats☆

Hannele Huuskonen, Virva Saastamoinen, Hannu Komulainen, Jarmo Laitinen, Jukka Juutilainen

Journal:

Reproductive Toxicology

Year:

2000

Language:

english

File:

PDF, 280 KB

english, 2000

45

TCDD Reduces Serum Melatonin Levels in Long-Evans Rats

Raimo Pohjanvirta, Jouko Tuomisto, Jere Linden, Jarmo Laitinen

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1989

Language:

english

File:

PDF, 214 KB

english, 1989

46

Intracerebroventricular antisense knockdown of Gαi2results in ciliary stasis and ventricular dilatation in the rat

Kati S Mönkkönen, Juhana M Hakumäki, Robert A Hirst, Riitta A Miettinen, Christopher O'Callaghan, Pekka T Männistö, Jarmo T Laitinen

Journal:

BMC Neuroscience

Year:

2007

Language:

english

File:

PDF, 1.80 MB

english, 2007

47

Mutagenesis of Human Mel1aMelatonin Receptor Expressed in Yeast Reveals Domains Important for Receptor Function

Tarja Kokkola, Marie-Ange Watson, Julia White, Simon Dowell, Steven M. Foord, Jarmo T. Laitinen

Journal:

Biochemical and Biophysical Research Communications

Year:

1998

Language:

english

File:

PDF, 124 KB

english, 1998

48

Pineal muscarinic phosphoinositide response: Pertussis toxin resistant signaling with very low receptor number

Jarmo T. Laitinen, Tichomir Torda, Juan M. Saavedra

Journal:

Biochemical and Biophysical Research Communications

Year:

1989

Language:

english

File:

PDF, 2.57 MB

english, 1989

49

The relationships between human serum pseudocholinesterase, lipoproteins, and apolipoproteins (APOHDL)

Reijo Jarmo Johannes Ryhänen, Matti Sakari Jauhianen, Matti Veikko Laitinen, Eino Vertti Puhakainen

Journal:

Biochemical Medicine

Year:

1982

Language:

english

File:

PDF, 258 KB

english, 1982

50

The chick retinal melatonin receptor revisited: localization and modulation of agonist binding with guanine nucleotides

Jarmo T. Laitinen, Juan M. Saavedra

Journal:

Year:

1990

Language:

english

File:

PDF, 439 KB

english, 1990

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